Case Study: Contamination Control Strategy (CCS) Implementation in Aseptic Biologics Manufacturing

Case Study Overview

Contamination Control Strategy (CCS) is now a cornerstone of EU GMP Annex 1 compliance. For biologics manufacturers, gaps in sterility assurance or Environmental Monitoring can lead to failed inspections, product risks, and reputational damage. This case study shows how GMP Bridge helped a mid-sized manufacturer in the DACH region design and implement a compliant CCS, strengthen oversight, and achieve inspection readiness ahead of schedule.

The Challenge

A mid-sized biologics manufacturer in the DACH region needed to rapidly align with the revised EU GMP Annex 1 requirements. Sterility assurance processes were fragmented, Environmental Monitoring lacked risk-based design, and an upcoming health authority inspection was approaching with identified compliance gaps. Without a structured Contamination Control Strategy, the site risked critical findings and delays to market supply.

Quick Summary

Region: DACH (Germany, Austria, Switzerland)
Company Type: Mid-sized biologics manufacturer
Products: Monoclonal antibodies, sterile drug products

Solution Delivered

Designed and implemented a site-wide CCS program tailored to Annex 1.
Conducted a comprehensive Contamination Control Risk Assessment (CCRA) to prioritize risks.
Built a Quality Oversight Program to strengthen governance of aseptic processes.
Optimized Environmental Monitoring strategy and sampling plans for compliance and efficiency.
Delivered aseptic behavior training to QA and production teams.
Supported SOP development and documentation updates for long-term sustainability.

Impact and Results

CCS fully implemented and auditable before the scheduled inspection.
Inspection readiness achieved with restored regulatory confidence.
Sterility assurance framework strengthened across all aseptic operations.
Risks systematically mitigated through risk-based action plans.
Ownership culture enhanced through a dedicated oversight program.

Want to see how we can deliver results like this for your site?