Case Study: Manufacturing Strategy & Quality Oversight Program for a Clinical-Stage Biotech Using CDMOs

Case Study Overview

For clinical-stage biotechs moving toward Phase III, defining a manufacturing strategy and building effective CDMO Quality Oversight are critical. Without structured governance, outsourced operations can cause delays, compliance gaps, and investor concerns. This case study shows how GMP Bridge supported a biotech with facilities in North America and Europe by delivering a risk-based manufacturing strategy and implementing a robust Quality Oversight framework.

The Challenge

A fast-growing clinical biotech preparing for Phase III needed to define its manufacturing approach while scaling operations. With multiple CDMOs, no formal oversight model, and increasing delays in batch release, the company required strategic guidance and hands-on implementation to regain control over outsourced manufacturing.

Quick Summary

Region: North America and Europe
Company Type: Clinical-stage biotech preparing for Phase III
Products: Recombinant proteins and sterile drug product (vials)

Solution Delivered

Conducted a make-or-buy analysis to guide in-house vs. outsourced production decisions.
Evaluated CDMO partners from a Quality and compliance risk perspective.
Defined optimal manufacturing setup to support late-phase and commercial goals.
Established a formal Quality Oversight framework and governance model..
Introduced KPIs to monitor CDMO performance and drive accountability.
Implemented structured oversight routines for batch release, deviations, and change control.

Impact and Results

Clear, risk-based manufacturing strategy aligned with development and commercialization plans.
Reduced batch release delays and faster deviation resolution.
A robust Quality Oversight Program ensuring tighter control over external manufacturing.
Improved collaboration and accountability with CDMO partners.
Strengthened investor and regulatory confidence in supply chain reliability.

Want to build a stronger manufacturing strategy and take control of your CDMO relationships?